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eMediNexus 20 January 2023
Alopecia areata (AA) is a nonscarring hair loss interceded by T lymphocytes. Recent evidence has shown that Janus kinase inhibitors are effective in treating AA in children.
The present study conducted a systematic review and meta-analysis according to the PRISMA guidelines. It defined good response as a more than 50% decrease in Severity of Alopecia Tool (SALT) score or complete regrowth or more than 50% regrowth; partial response as a 5% to 50% decrease in SALT score and any response to treatment as more than 5% in SALT score decrease.
The study observed:
This study shows a promising effect of Janus kinase inhibitors in treating AA in children, with the most common side effects being minor and reversible.
Source: Chen Y, Zhu H, Shen Y, et al. Efficacy and safety of JAK inhibitors in the treatment of alopecia areata in children: a systematic review and meta-analysis. J Dermatolog Treat. 2022;33(8):3143-9.
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